Sle another autoimmune disorder influenced by microbes and diet

In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. In human SLE, a recent cross-sectional study has shown that a lower Firmicutes to Bacteroidetes ratio was present in women with SLE even after disease remission In addition to microbes, a number of environmental triggering factors have been described to be associated with SLE, including UV light and cigarette smoking, some of which trigger lupus through epigenetic mechanisms 27 — Qin et al.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. One recent study has described diet-mediated increases of specific microbial genera that are known to be lower in SLE Fecal transplant of male gut microbiota to female mice ameliorated the disease and increased testosterone.

Dietary Components and SLE Diet, one of the main environmental factors with known effects on gut microbiota, has been studied extensively in both SLE patients and lupus-prone mice.

However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. Systemic lupus erythematosus is a female-biased disorder.

In addition, bacterial metabolites produced by gut microbes can modulate immune function.

Lupus: Can Gut Microbes Make a Difference?

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However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. In addition, in a large serologic survey, Helicobacter pylori seronegativity was found to be associated with an increased risk and earlier onset of SLE in African Americans, suggesting a protective role of H.

Data from several regions of USA show that the incidence of SLE increased at least threefold within the second half of the twentieth century 31 The function of microbiota in T1D is found to be highly associated with sex hormones.

In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. The prevalence ranges from 20 to cases perpersons, with higher prevalence for people of African, Hispanic, or Asian ancestry 19 This may be due to the different genetic backgrounds of the mice strains.

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Recently, several groups have found that metabolites produced by gut bacteria, especially butyrate produced by Clostridia, can promote the differentiation of regulatory T cells Tregs in the colon, spleen, and lymph nodes to suppress inflammation 59 — Importantly, the improvement was highly associated with the ability of tRA to restore Lactobacilli In SLE patients, some benefit of tRA to ameliorate lupus nephritis and proteinuria has been reported 79 Infections from pathogenic microbes, or the lack thereof, are known to be associated with SLE occurrence.Researchers at Virginia Tech have recently discussed the contribution of diet and gut microbes to SLE occurrence and pathogenesis in a publication entitled “ SLE: Another Autoimmune Disorder influenced by Microbes and Diet?” published in the journal Frontiers in Immunology.

· Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new ancientmarinerslooe.com by: 2.

November | Volume 6 | Article Mu et al. Is SLE Infiuenced by Microbes and Diet Frontiers in Immunology | ancientmarinerslooe.com lupus symptoms in lupus mice also restored gut colonization of.

· SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Qinghui Mu, 1 Husen Zhang, 2 and Xin M. Luo 1, * 1 Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USACited by: Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Qinghui Mu 1, Husen Zhang 2 and Xin M. Luo 1 * 1 Department of Biomedical Sciences Cited by:

Sle another autoimmune disorder influenced by microbes and diet
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